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It is evident that a combination of genetic, physiological, behavioral, socioeconomic, and sociocultural factors underlies each of the three phases of smoking behavior (i.e., initiation, intensity, cessation) 59

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Epithelial barrier integrity is also adversely affected following exposure to a diverse range of inhaled substances including diesel exhaust particulates, ambient particulate matter, acrolein, asbestos, ozone, wood smoke particulates, and e-cigarette flavorings (Yu et al., 1994