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& Daneshvar, D

L.et al (2007)

Consistent with this, activated microglia form clusters around blood vessels in hypertensive eyes (110) and dendritic and synaptic architecture in rodent glaucoma can be protected not only by inhibiting the C1q protein or deleting its gene, but also by blocking pressure-induced immigration of macrophages/monocytes (60, 81)

Then, MPO triggers a series of reactions to disrupt chromatin packaging and works synergistically with neutrophil elastase (NE) to decondense chromatin