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The migration of cisplatin to kidney cells proceeds via two transporters: a copper transporter Ctr1 [65] and the organic cation transporter OCT2 [66]

Am J Respir Crit Care Med 158:395403 Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H et al (2018) Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

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Third, both studies support a division of labor among E2s: Ube2e2 family members are not sufficient to drive substrate ubiquitination with COP1 alone, whereas Ube2d3/UbcH5 enzymes support chain building within CRL4 DET1-COP1 assemblies