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More specifically, the results revealed that daily e-cigarette users were significantly more likely to develop ED compared to the participants who did not smoke, both in the overall sample and the sample of men without history of CVD

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A Cochrane Living Systematic Review reports high-certainty evidence that nicotine e-cigarettes lead to higher quit rates than NRT, with a risk ratio of 1.55 , corresponding to three to six additional quitters per 100 users (Source: The 12-Week Tapering Model: How Reduction Actually Works Once smoking behavior is stabilized, effective protocols introduce a structured 12-week taper that alternates between two variables: Nicotine concentration reduction (typically in 2025% steps) Time-based use restriction , such as eliminating morning use first, then restricting vaping before work hours, and eventually limiting all use to short evening windows A pharmacist-led case report demonstrated that this alternating strategy enabled participants to reach complete nicotine abstinence by week 12 , without relapse (Source: A pilot study comparing cessation methods found that participants following a vape-taper protocol combined with behavioral support achieved a 75% nicotine-free rate at six months , outperforming both NRT and self-guided cessation approaches (Source: Addressing Compensatory Puffing: An Important Safety Consideration One important physiological challenge identified in recent trials is compensatory puffing