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Higgins JPT, Altman DG, Sterne JAC: Chapter 8: Assessing risk of bias in included studies Version 5.1.0 (updated March 2011)

64 Moreover, epigenetic changes in aged HSCs impair differentiation, including disrupted DNA methylation and histone modifications

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Conclusion: Our study suggests that MSM ameliorates hepatic steatosis by enhancing the autophagic flux via an AMPK/mTOR/ULK1-dependent signaling pathway

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These exceptionally large repeat expansions demonstrate striking cellular specificity, being predominantly localized to MSNs ( Genome-wide association studies have identified potential genetic modifiers, including mismatch-repair (MMR) genes ( MSH3 , MLH1 , PMS1 and PMS2 ) and other DNA repair genes ( FAN1 and LIG1 ) ( MSH3 , PMS1 , MSH2 and MLH1 ) ameliorates both early-onset phenotypes in MSNs and late-onset manifestations in cortical neurons, including somatic CAG-repeat expansion, transcriptionopathy and mHTT aggregation ( MSH3 deficiency specifically improves open-chromatin dysregulation in neurons