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Estimates and projections of the global economic cost of 29 cancers in 204 countries and territories from 2020 to 2050

This work suggests that increases in oxygen demand alone are sufficient to cause kidney disease as seen in the diabetic kidney

& Hsiao, C.-H

First, the crosssectional design precludes causal inference

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Citrate produced via the TCA cycle or reductive carboxylation is exported to the cytoplasm and converted by ATP-citrate lyase (ACLY) into acetyl-CoA, fueling de novo lipogenesis through fatty acid synthase (FASN) and acetyl-CoA carboxylase (ACC) [231, 232]