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Front Immunol (2021) 12:709178

Apart from the strong oxidizing properties of its associated oxidants, MPO, as a strongly basic protein, can also bind to the negatively charged glycocalyx on the surface of several cell types, such as epithelial and endothelial cells [312, 313], macrophages, or neutrophils [313]

Recent research into microglia and HIV-1 factors has underscored the central mechanisms involved in this process include NLRP3 inflammasome activation (e.g., GSDMD, GSDME, NEK7, ASC, caspase-1 and IL-1) and NF-B signaling pathways (e.g., NF-B, P2X7R, IKK, nuclear translocation inhibitors, DNA binding inhibitors), along with cellular processes such as autophagy (e.g., PINK1, Parkin and DNM1L), ferroptosis (e.g., FTH1, ACSL4, miR-204, and GPX4), and senescence (e.g., miR-505 and SIRT3), highlighting critical targets for further investigation and therapeutic intervention in NeuroHIV

6 Nonimaging Diagnosis 6.1 Gut Microbiota The gut microbiota has become a new focus of various diseases, including chronic liver disease (67), type 2 diabetes mellitus (68), inflammatory bowel diseases (69), cardiovascular disease (70), sarcopenia (71) and cancer (72)

Croteau W, Whittemore SK, Schneider MJ, Germain DL

Natl J Maxillofac Surg 2017