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Apart from the genetic mutations, other experiments have proven that it is the lack of taurine conjugation to the tRNALeu(UUR) that leads to MELAS syndrome

10.1016/j.freeradbiomed.2020.02.027 [DOI] [PubMed] [Google Scholar] Verma S., Crawford D., Khateb A., Feng Y., Sergienko E., Pathria G., et al

This is why supplementation has gained enormous traction, especially in oral form, which supports systemic antioxidant protection rather than just surface-level application

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It is the route documented for the overwhelming majority of research peptides

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