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( a ) Representative flow cytometry plot showing proportions of donor (CD45.2) and recipient (CD45.1) derived haematopoietic cells in spleens of chimeric mice generated using the CRISPR-Cas9 based approach

Table 1 Characteristic of studied group and control group

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Anti-LC3B (D11), anti-GAPDH antibodies, and senescence -galactosidase staining kit were purchased from Cell Signaling Technology (Danvers, MA, USA)

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