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doi:10.3233/JAD-181148 Maltais M, de Souto Barreto P, Bowman GL, et al

Mechanical forces can lead to changes in DNA methylation, histone modifications, and non-coding RNA expression, which in turn affect gene expression and cellular behavior

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Because it's shown promise in protecting mitochondria - the tiny structures that serve as the energy-producing powerhouses of cells that weaken as the decades tick by - people have started to promote methylene blue as a way to slow cellular aging, including in the brain