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Metformin promotes the hair-inductive activity of three-dimensional aggregates of epidermal and dermal cells self-assembled in vitro

This could be due to differences in (1) mode of action in different cell types (2) adaptation mechanisms or (3) off-target effects of GLS1i

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This form is used specifically for oral delivery due to its improved stability compared to acetate versions

doi: 10.3389/fmolb.2022.958586 Received 31 May 2022 Accepted 22 June 2022 Published 12 August 2022 Volume 9 - 2022 Edited by Simona Piaggi, University of Pisa, Italy Reviewed by Ozlem Dalmizrak, Near East University, Cyprus Bengt Mannervik, Stockholm University, Sweden Updates Copyright 2022 Sylvestre-Gonon, Morette, Viloria, Mathiot, Boutilliat, Favier, Rouhier, Didierjean and Hecker