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Curtis EM, Moon RJ, Harvey NC, Cooper C

1 Introduction Gliomas are the most common primary malignant tumours of the central nervous system (CNS), accounting for approximately 30% of all primary brain and CNS tumours and 80% of malignant brain tumours ( 7 and O 6 sites of guanine and at the N 3 site of adenine

Moreover, although certain peptides exhibit cell-penetrating properties, their translocation efficiency remains generally low, particularly across stringent biological barriers such as the BBB, restricting their therapeutic applicability in hard-to-treat diseases (Table 2)

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The addition of vitamin E to the incubation medium inhibited further progression of cataracts, reduced increases in lipid peroxide levels and the Na + /K + ratio, and ameliorated decreases in reduced glutathione, glyceraldehyde-3-phosphate dehydrogenase, and Na + /K + -ATPase activities (50)

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