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Complications of coeliac disease include adverse reproductive outcomes, kidney and liver disease, infections, other autoimmune disease, certain cancers and neurological and psychiatric disease, reflecting the multisystemic nature of the disease

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This effect results from Depo-Proveras suppression of ovulation combined with thinning of the endometrial lining , making bleeding less likely to occur

Long-term low B12 can drive elevated homocysteine and contribute to megaloblastic or pernicious anemia

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A recent review in the journal Cureus compares the natural forms of B12 found in the diet with synthetic B12 (cyanocobalamin) in terms of absorption and clinical-physiological effects