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Other risk factors for B12 deficiency are stress, excessive alcohol use, and smoking

doi: 10.1016/j.brainres.2010.02.031 79

Reactive oxygen species (ROS), a group of highly reactive molecules containing oxygen, including superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), singlet oxygen, and hydroxyl radicals (OH), can interact with lipids, proteins, and nucleic acids within cells, leading to oxidative stress [5]