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Subsequent experiments demonstrated that apigenin inhibited the IKK activity to promote the cleaved caspase 3 expression, allowing the apoptosis of pancreatic cancer cells [63]

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This result was not attributable to publication bias, or a significant between-studies heterogeneity

This is done by the induction of cellular apoptosis, regulation of autophagy, endoplasmic reticulum (ER) stress modulation, unfolded protein response (UPR) modulation, and epigenetic regulation [47]

In addition, AMPK can improve DCM by regulating glycolipid metabolism, regulating protein synthesis and degradation, affecting the transcription of proteins related to gluconeogenesis, lipogenesis, and mitochondrial biogenesis, and regulating vascular endothelial dysfunction

The results of this study may provide novel insights for developing postharvest quality control technologies for broccolini and the genetic improvement of broccolini varieties