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Based on structural and functional differences, the family is divided into two groups: Rel proteins (RelA, RelB, and c-Rel), which possess transcription activation domains (TADs), and NF-B1 and NF-B2, which lack TADs in their mature forms (p50 and p52) and require co-activators such as Bcl-3 for transcriptional activity [6]

It is widely recognized that eicosanoids, which are generated through the COX-2 and 5-LOX pathways, play a role in the advancement of colon cancer

A precursor for glutamate called alpha-ketoglutarate is created in the mitochondria in the TCA cycle (Krebs cycle, producing ATP energy)

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Many find adequate results at 10 mg or 12.5 mg with fewer side effects

Trends Cardiovasc Med (2008) 18(1):614