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However, limitations exist in the form of in vivo instability, the reliance on carriers that are biocompatible and robust and limited sites of application (local and direct) (Park et al

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Notably, exosomes derived from brain endothelial cells were employed to deliver PTX and DOX across the BBB in zebrafish glioblastoma models, achieving superior drug accumulation in brain tissues and greater cytotoxic effects against glioma cells compared to free-form drugs [56]

This structural simplicity facilitates its chemical synthesis by SPPS (Solid-Phase Peptide Synthesis) in standard Fmoc chemistry, with high yields and without oxidative folding complications

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