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These are G protein-coupled receptors (i.e., metabotropic

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Exposure to pristane causes lupus-like disease that is characterized by interferon(IFN)-I-dependent autoantibody production, inflammatory cytokines and renal diseases in susceptible mouse models ( Induction of pristane-induced autoantibodies has been shown to be dependent on the inflammatory cytokines as protective effects on nephritis and autoantibodies were observed in INF- / , IL-6 / , IL-12 / , and IL-17 / mice ( Silica Among the environmental and occupational agents associated with immune dysregulation, silica is considered a notable risk factor due to its widespread exposure