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Current clinical consensus is that combination therapy remains investigational and should only be pursued under physician supervision with baseline and monthly labs, especially for metabolic markers and cardiovascular safety

These findings offer epidemiological support for lifestyle-based interventions that target both movement and micronutrient sufficiency to delay age-related physiological decline ( In contrast, the DO-HEALTH randomized clinical trial, which enrolled over 2,150 older adults across Europe (mean age of 75 years), tested a combination of vitamin D3 supplementation (2000 IU/day), omega-3 fatty acids (1 g/day), and a strength-training program over a three-year period