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10.1038/s41589-020-0613-y 124 StockwellB

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In vivo and in vitro studies have reported that EE itself is biotransformed for excretion mainly by glucuronidation (85%) and sulfation (12%) and that hydroxylation (mainly by CYP3A4 and CYP2A9 on C2) occurs only at low levels 22

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