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favor fluid, electrolyte, and acid/base homeostasis

References 8 and 10 show that DNMT3L interacts with unmethylated H3K4 through its N terminus and with DNMT3A through its C terminus, thus linking the DNA methylation machinery to the modification state of histone tails

The APOE genotype (Alzheimers risk factor) associates with distinct microbiome profiles (differences in Prevotellaceae , Ruminococcaceae , butyrate producers [96]), suggesting the microbiome-gut-brain (MGB) axis mediates genetic risk