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VD deficiency results in neuronal cell death by inducing neuroexcitatory toxicity via triggering a sudden increase in cytoplasmic Ca 2+ , elevating ROS generation, and inducing mitochondrial dysfunction

Oxidative stress regulation, calcium homeostasis, mitochondrial dynamics, mitophagy, and biogenesis remain in continuous cross-talk to preserve bioenergetic stability, prevent cytotoxic leakage, and maintain cellular resilience

[DOI] [PubMed] [Google Scholar] Oyadomari S., Harding H.P., Zhang Y., Oyadomari M., Ron D

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