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On the other side, extracellular superoxide dismutase (EC-SOD) has a strong affinity for glycosaminoglycan like heparin and heparin sulphate

Li Y, Huang R, Li X, Li X, Yu D, Zhang M

Biochemical reports also demonstrated that enhanced oxidative stress, dysregulated apoptosis, and extensive inflammatory reactions mediated by overexpressed inflammatory factors [such as tumor necrosis factor (TNF-), interleukin 1 (IL-1), and interleukin 6 (IL-6)] were served as the underlying mechanisms for the occurrence of various CSD-relevant diseases (810)

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Similarly, targeting ERK, the final downstream kinase of the MAPK signaling pathway, has shown potential

PMID: 41203627 Acta Pharmacol Sin Targeting PPAR activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation