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However, administration of GH and subsequent GH-mediated effects were found to be dose dependent, as high concentrations given to GH-deprived canines caused atrophy of testes and accessory organs, thinning of prostatic epithelium and a reduction in LH and testosterone levels (75)

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World J Gastroenterol 19:27612771 Tian X, Ruan J, Huang J, Fang X, Mao Y, Wang L, Chen X, Yang C (2016) Gossypol: phytoalexin of cotton