Fmoc-Val-Cit-PAB(m-PEG4) cleavable 263 SMILES BrCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

263 SMILES BrCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

NRX-252114 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome

and lung cancers

335 SMILES OCCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

411 SMILES OCCCCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Fmoc-Val-Cit-PAB(m-PEG4) cleavable 263 SMILES BrCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned