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doi: 10.1016/B978-0-12-802168-2.00038-5 173 FloheLGnzlerWASchockHH

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R.ShiehY.GulasarianA.OlsonJ.RustandiR

Here we show that SIRT3, a mitochondrial deacetylase highly expressed in HSCs but reduced during aging, suppresses the HSC response to aging that drives maladaptive trained immunity, chronic inflammation and tissue functional decline in mice

Les radicaux libres sont des molcules contenant des lectrons non apparis, ce qui les rend trs ractifsii