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Studies suggest that mycobiome dysbiosis triggers pro-inflammatory responses, leading to the transformation of epithelial cells and DNA damage, ultimately imparting a carcinogenic effect [32]

Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling

Here they found that glutathione is not beneficial enough as a skin-whitening agent as it was only effective in some parts of the body and did not elicit long-lasting effects. Another study published in the DPC journal attempted to understand the connection of glutathione as a treatment for hyperpigmentation

doi: 10.3238/arztebl.2010.0446 30 PeiyinFYuxianWJialiZJianX

see also, Snijders et al., 2021)

The mechanisms by which olive leaf polyphenols exert their effects include the modulation of the NF-B inflammatory response and the oxidative stress response