Clinical evidence further substantiates lactate's pathological significance: urinary lactate levels in DKD patients show significant positive correlations with renal function indicators such as 24-h urinary albumin excretion and serum creatinine levels [35]

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The protective effect of UA in parkinsonian model systems is also found to be dependent on Glut9-mediated transport, which is upregulated by UA in dopaminergic neurons in vitro 38
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Three-dimensional culture has been shown to more closely approximate the behaviour of the primary tumour 19
J Am Chem Soc 144:72837294 Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A et al (2019) Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma