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Similarly, another study reported that rutin-loaded chitosan nanoparticles demonstrated selective cytotoxicity, exerting minimal effects on normal fibroblasts while inducing significant cytotoxicity in hepatocarcinoma cells, along with favourable haemocompatibility [190]

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Other studies have shown that TRIM46 enhances lipid peroxidation and ferroptosis in HRCECs stimulated by high glucose through promoting GPX4 ubiquitination (178)

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