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10.1038/ncomms1914 12 BoscoloP.GioacchinoD.Di GiampaoloM.AntonucciL

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The non-esterified fatty acids (NEFA) and -hydroxybutyric acid (BHB) may lead to oxidative stress followed by an enhancement of the lipolysis process (78)

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Medications and supplements can be tried, but liposuction should be considered for women with lipedema who fail conservative measures and following weight loss with medications and/or bariatric surgery