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Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation

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To promote NADPH supply, pentose phosphate pathway ( ZWF1 ) and gluconeogenesis ( FBP1 and PCK1 ) are adopted

GR-D isoforms have the lowest in vitro transcriptional regulatory activity

We have previously shown that schistosome redox defenses are limited, and that as such they can be disrupted pharmacologically leading to worm death in vitro and in vivo 15