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In addition, the pathways Lipid and atherosclerosis and Fluid shear stress and atherosclerosis may be involved in lipid metabolic disease

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Dor S (2002) Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimers disease

NOCs can lead to DNA alkylation, which can induce genetic mutations that ultimately lead to cancer ( 2 S, which can promote the occurrence of CRC by inhibiting butyrate oxidation, destroying the intestinal barrier, and interacting with ROS to induce DNA damage ( Dietary fiber can increase intestinal peristalsis, promote stool excretion, and reduce the food transit time in the colon, thus reducing the contact time of potential carcinogens with intestinal mucosa ( 2.1.2 Familial inheritance Approximately 20-30% of CRC cases are associated with genetic factors, 2-5% of CRC is caused by inherited syndrome, mainly including Lynch syndrome, familial adenomatous polyposis, juvenile polyposis syndrome, MUTYH -associated polyposis, and Peutz-Jeghers syndrome etc ( 2.1.3 Polyps The incidence of CRC is closely related to polyps

Bacterial fermentation occurs when dietary fibers enter the colon (45), and as a result, they produce short-chain fatty acids (SCFAs such as acetic acid, propionic acid, and butyric acid) (46), biogenic amines (47), indole and tryptophan derivatives (48), and secondary bile acids, conferring a health benefit

[DOI] [Google Scholar] 27.Goldfarb R.J., Berger B.R., George M.W., Seal II R.R