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As the infection progresses, the interaction between the pathogens and host cells becomes more complex

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In the lamina propria, some GIP glutamines are deamidated to glutamate by transglutaminase 2 (TG2) (Zhuang and Khosla, 2020) and subsequently bind to antigen-presenting cells (APCs)dendritic cells, macrophages, and B cells (Wei et al, 2020)previously activated by pro-inflammatory cytokines such as interleukin (IL)-15 and type-1 interferons (IFNs)