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The PINK1/Parkin-mediated mitophagy is triggered when PINK1 is stabilized on the outer membrane of damaged mitochondria and recruites Parkin, an E3 ubiquitin ligase, followed by ubiquitination of mitochondrial proteins, which are then recognized by autophagy receptors [41]

Costa, J.M

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In 1872, Bierner named it pernicious anemia

Treatment typically focuses on lifestyle modifications (avoiding late meals, elevating the head of the bed, weight loss when appropriate) and medications that reduce stomach acid