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For instance, GHRH analogs like tesamorelin may cause water retention-related issues, including joint pain, limb edemas, and carpal tunnel syndrome [28]

International Journal of Pharmaceutics

Availability of data and materials They are available from the corresponding author on reasonable request

Last reviewed: June 4, 2026 Last updated: June 4, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

M.SofiaA.MilanesiS.et al (2019)

These injections tend to be much more effective in controlling pain and keeping the pain under control than oral medications while avoiding systemic side effects such as gastritis and kidney problems