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Important considerations: Cardiac or renal disease: patients with heart failure or poor kidney function need evaluation due to fluid and electrolyte risks

Significantly, the nanocomposite exhibited no harm to mammalian cells, revealing its non-toxic nature [183]

Under conditions of metabolic stress, it migrates to the cell nucleus, where it activates a suite of genes governed by AMPK (AMP-activated protein kinase), the master cellular energy sensor