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VNS has previously been shown to alleviate chronic depression by modulating the HPA axis and reducing the CRH (corticotropin-releasing hormone)/ACTH (adrenocorticotropic hormone) response (95)

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mRNA-based therapies provide a versatile tool for fine-tuning gene expression (Qin et al., 2022)

38,39,46,54,55 Combination Preventive Therapy Up to 60% of patients achieve some improvement with preventive monotherapy, but approximately 30% fail to respond or cannot tolerate the available medications, especially the nonmigraine mechanism specific oral agents

Older age is a risk factor, as pernicious anemia is more common in individuals over 60