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10.1038/nchembio.2079 123 ShouY.YangL.YangY.XuJ

Therapeutic approaches such as antioxidant therapy, mitochondrial-targeted compounds, and lifestyle modifications present promising opportunities to mitigate mitochondrial dysfunction and alleviate the side effects associated with iron overload

The mechanisms by which the rod penetrates and then multiplies in the host cells are still being intensively studied

An untold number of lives, perhaps tens of thousands, have been saved by vaccination

Although considerable progress has been made in understanding the role of astrocytes dysfunction and BBB impairments in PD initiation and progression, major gaps remain in defining causality, mechanisms, and translational significance (Figure 2)