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[3] Examples of activation-independent carcinogens include ultraviolet light, ionizing radiation and alkylating agents

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Firstly, the CHRNB2 associations were based on European ancestry from the UKB (the main rare variant driving the CHRNB2 association occurs only in Europeans) and the CHRNB3 associations were based on Indigenous Mexican ancestry from the MCPS (the main rare variant driving the CHRNB3 association occurs only in Indigenous Mexicans)