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They are useful tools, but they capture a snapshot of tissue-level data that lags behind what the patient experiences

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The presence of insulin resistance and elevated pro-inflammatory cytokines (e.g., tumor necrosis factor-) induce hepatic GH resistance (64), causing increases in GH and decreases in IGF-I levels ( Table 1 )

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These findings indicate that activating Nrf2 by GLP-1 and its subsequent antioxidative effects may have potential benefits in preventing and treating DM, as well as reducing the likelihood of complications

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