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Chitnis MM, Yuen JSP, Protheroe AS, Pollak M, Macaulay VM

Substance P, in particular, plays a significant role in: amplifying pain signals

What the Authoritative Sources Say About B12 Deficiency and Supplementation The National Institutes of Health Office of Dietary Supplements publishes the most thorough citation-backed overview of vitamin B12 its role in red blood cell formation and neurological function, the populations most at risk for deficiency (older adults, people on long-term metformin or proton pump inhibitors, vegetarians and vegans, people who have had gastric bypass surgery), and the recommended daily intake at each life stage

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Recommended Dosages and Forms Vitamin D and B12 deficiencies can cause serious symptoms