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this corresponds exceptionally well with previous reports of heritability (87 93 %) in the affluent societies of Western Europe [28]

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The Tier 1 CGS showed significant associations with both fibrosis and MAS, as did the prior 3 allele CGS (Rsquared for fibrosis 0.099 and 0.099, Rsquared for MAS 0.013 and 0.014), but for both traits this appeared driven by the PNPLA3 rs738409 (Rsquared for MAS 0.013 and 0.014) (Table1)

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