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Over time, the condition will eventually cause the following: A persistent cough Coughing up blood Persistent breathlessness Unexplained tiredness and weight loss An ache or pain when breathing or coughing

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These labels are so problematic that the Food and Drug Administration has required Santa Fe Natural Tobacco Company, the maker of Natural American Spirit cigarettes, to remove the terms natural and additive-free from its product labels, advertising and promotional materials because they constitute reduced harm claims, which are banned without agency approval