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Once activated, SIRT1 deacetylates and activates PGC-1, the master transcriptional coactivator that directly commands the cell to build new mitochondria

Funding This work was supported by the European Community under Innovative Medicines Initiative (IMI) Program (Grant No

Cell viability was measured by adding 10 L of 10% CCK-8 reagent per well, incubating for 1 h at 37C, and reading absorbance at 450 nm

M.YuanJ.DeSantisT

T cells accumulate in the intestine before arthritis onset To investigate cellular intestinal alterations that precede the onset of arthritis in more detail, we analyzed T-cell subsets in the intestine at different time points during the CIA time course

Several strategies have been proposed to alleviate this damage, including cell transplantation 4,5,6,7 and gene therapy 8,9,10,11