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Improves Cardiac Function: Increases cardiac output and left ventricular function independently of GH, likely through myocardial GHS-R1a activation 3

Interestingly, the exhaustive analysis of these responses has helped to decipher alternative pathways that are not regulated by classical estrogen receptors and are triggered by estrogen mimetics

This condition, termed Hypothalamic Syndrome (HS), encompasses a spectrum of symptoms, including hypothalamic obesity (characterized by rapid, uncontrollable weight gain despite caloric restrictions), disordered eating behaviours (uncontrollable hyperphagia, insatiable hunger, food-seeking behaviour), neurocognitive and behavioral changes (memory deficits, emotional lability, depression), sleep disturbances (hypersomnia, narcolepsy, circadian rhythm disruption), fatigue, and autonomic dysfunction (imbalances in body temperature, thirst, heart rate, and blood pressure regulation) [85, 86]

This condition primarily involves the infundibular area of hair follicles, leading to occlusion, dilation, rupture, and inflammation of the follicle

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