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Cox JD, Hahn S, Komaki R, Swisher SG , Gomez D, OReilly M, Jeter M, Gillin M, Zhu XR, Zhang X, Chang J

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Ubiquitin-mediated protein degradation by the UPS was discovered in the 1980s, and begins with the poly-ubiquitination of the target, that is, with the addition to the protein to be degraded of several ubiquitin units - a 76-aminoacid regulatory protein of globular conformation 12,13

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