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These findings indicate that polysaccharides extracted with citric acid could be developed as bioactive ingredients for both food and medicinal applications

Other participants in the TCA cycle are also more active in KRAS-mutant tumors, particularly in pancreatic ductal adenocarcinoma (PDAC), where the increased expression of GOT1/2 supports glutamine metabolism while producing NADPH to maintain REDOX balance [50]

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examined 41 tissue samples (including 9 papillary thyroid cancer tissues) (97) and found that their Se levels and GPx activity were lower than those of non-cancerous tissues, while malondialdehyde (MDA) concentrations were increased

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Overall, inhibition of the PKC pathway, particularly through selective blockade of PKC- isoforms, has shown promise in animal models for alleviating diabetic cardiovascular complications by reducing oxidative stress, enhancing endothelial function, and preserving myocardial integrity