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In addition, hypoxia induces RA tissue to switch from oxidative phosphorylation to glycolysis by activating HIF-1, reprogramming the energy metabolism pathway of cells (124, 125)

180 SupinoR.MapelliE.SanfilippoO.SilvestroL

Ferroptosis occurs when oxidative stress causes excessive damage to membrane lipids

Piribedil was found to be effective in RLS treatment

Therefore, using multiple carriers can further improve the stability of EO, achieve slow release, and enhance therapeutic effects (Chakroun et al., 2023)