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Regulation of human macrophage M1-M2 polarization balance by hypoxia and the triggering receptor expressed on myeloid cells-1

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Pereira-Coelho M, da Silva Haas IC, Vitali L, dos Santos Madureira LA

During initiation, cells export reduced GSH through plasma membrane transporters before membrane rupture, establishing a redox environment permissive for apoptotic signaling

The reported outcome of this campaign was a candidate that retained agonist activity at amylin/calcitonin-family receptors while displaying a markedly extended pharmacokinetic profile in the authors' preclinical models, and reduced food intake in rodent models following administration

NOX-derived ROS also promotes increased OXPHOS, and TCA cycle activity that provides intermediates for amino acid synthesis