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Soluble Vpr released from infected microglia activates HIF-1 and perturbs neuronalglial homeostasis, driving oxidative stress, elevation of intracellular Ca, excess ROS, and disruption of neuronal glutamatergic signaling [135, 136]

Mechanisms underlying stress effects on the brain: basic concepts and clinical implications

Transient headaches or lightheadedness during initial dosing

Inflammation of the kidneys filtering units, called glomerulonephritis, is responsible for about 10-20 percent of the extensive kidney damage patients experience, although the affected pathway is common to many forms of progressive kidney damage